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Carpometacarpal (CMC) arthritis ¡ª also known as thumb arthritis ¡ª is a common condition that affects the CMC joint, which is located at the base of the thumb (where it connects with the wrist). This type of arthritis can occur from overuse, repetitive tight gripping and pinching, age or injury to the joint. It can cause severe pain and make it difficult to complete easy daily tasks, like opening a jar or turning a doorknob.